Antimicrobial Activity of Turmeric, Ginger, and Galangal Rhizome Ethanol Extracts in Combination Using the Checkerboard Method

Muhammad Azhari; Riki Febriansyah Sengaji

doi:10.57174/j.born.v3i3.108

Penulis

Muhammad Azhari Department of Pharmacochemistry, School of Pharmacy, Institut Teknologi Bandung https://orcid.org/0000-0003-3966-582X
Riki Febriansyah Sengaji Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Al-Ghifari University

DOI:

https://doi.org/10.57174/j.born.v3i3.108

Kata Kunci:

jahe, kombinasi, kunyit, lengkuas, sinergis

Abstrak

Infeksi bakteri masih menjadi masalah besar di seluruh dunia dan memburuk dengan munculnya jenis bakteri yang resisten terhadap antibiotik. Indonesia kaya akan sumber daya alam, seperti keanekaragaman flora, dengan berbagai manfaat, termasuk untuk pengobatan. Penelitian ini bertujuan untuk menentukan potensi ekstrak etanol rimpang kunyit, jahe, dan lengkuas secara tunggal dan kombinasi menggunakan metode checkerboard terhadap beberapa patogen. Aktivitas penghambatan paling ampuh dalam bentuk tunggal ditunjukkan oleh ekstrak kunyit terhadap Streptococcus mutans dan Cutibacterium acne dengan nilai konsentrasi hambat minimum (KHM) sebesar 16 µg/mL, sedangkan aktivitas bakterisida paling baik ditunjukkan oleh ekstrak kunyit terhadap Staphylococcus aureus dan Enterococcus faecalis dengan KHM dan konsentrasi bakterisida minimum (KBM) sebesar 32 µg/mL. Kombinasi sinergis ditunjukkan oleh kunyit-jahe (TGi), kunyit-lengkuas (TGa), dan jahe-lengkuas (GiGa) terhadap Staphylococcus aureus dengan FICI (fractional inhibitory concentration Index) masing-masing sebesar 0,15625, 0,1328, dan 0,15625, dan TGi terhadap Streptococcus mutans dengan indeks konsentrasi penghambatan fraksional (FICI) sebesar 0,1875. Studi pendahuluan ini menunjukkan potensi rimpang tersebut untuk diteliti lebih lanjut guna mengetahui senyawa aktif yang memiliki aktivitas sinergis yang dapat digunakan sebagai terapi alternatif di masa depan.

Unduhan

Data unduhan tidak tersedia.

Biografi Penulis

Muhammad Azhari, Department of Pharmacochemistry, School of Pharmacy, Institut Teknologi Bandung

Department of Pharmacochemistry, School of Pharmacy

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