Studi Toksisitas Infusa Rimpang Pacing (Costus speciosus) dengan Metode Brine Shrimp Lethality Test (BSLT)

Benazir Evita Rukaya; Syuhada Syuhada; Fajar Wahyu

doi:10.57174/j.born.v4i3.155

Authors

Benazir Evita Rukaya Program Studi Ilmu Farmasi, Politeknik Kaltara, Kota Tarakan, 77113, Indonesia
Syuhada Syuhada Program Studi Ilmu Farmasi, Politeknik Kaltara, Kota Tarakan, 77113, Indonesia
Fajar Wahyu Program Studi Ilmu Farmasi, Politeknik Kaltara, Kota Tarakan, 77113, Indonesia

DOI:

https://doi.org/10.57174/j.born.v4i3.155

Keywords:

Costus speciosus, ınfusa, LC50, toksisitas

Abstract

Costus speciosus or Pacing, is a herbal plant that has long been used in traditional medicine in various Asian countries. This plant is reported to have biological activities such as antidiabetic, anti-inflammatory, and anticancer. However, information regarding its toxicity is still limited. This study aims to determine the toxicity of Costus speciosus rhizome infusion using the Brine Shrimp Lethality Test (BSLT) method. This method utilizes Artemia salina Leach larvae as a model organism to assess potential toxicity. Pacing rhizomes contain bioactive compounds such as flavonoids, saponins, and alkaloids with pharmacological potential. The results showed that pacing rhizome infusion has very high toxicity based on the Clarkson toxicity category with an LC50 value of 54.99 ppm. These findings provide a basis for further research on the safety and pharmacological applications of pacing rhizomes as herbal medicine ingredients.

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